Welcome to the Home Page of the Hayashi group in the Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science.

                                                                                                                                           Last Update: 2012.04.23 Since 2005.6.22

------------   update history of this homepage	Reactions	Total Syntheses
--------------  research of  the Hayashi laboratory

Prof. Hayashi was awarded Novartis Chemistry Lectureship. Chem. & Eng. News, Sep. 5, 2011. Angew. Chem., Int. Ed., 51, 2809 (2012).     Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile Chem. Commun.,48, 4570 (2012).  Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura and Hayato Ishikawa     High-Yielding Synthesis of the Anti-Influenza Neuramidase Inhibitor (-)-Oseltamivir by Three “One-Pot” Operations Most cited paper published in Angew. Chem. Int. Ed. from 2009 to 2010. Rank 4th Prof. Hayashi was awarded Inoue Prize for Science                                 Prof. Hayashi was awarded the Japanese Society for Process Chemistry Award 2011 for Excellence. Prof. Hayashi is an invited speaker at AIMECS11, Tokyo, on November 30 th. Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study J. Am. Chem. Soc., 133, 20175 (2011). Yujiro Hayashi, Hiroaki Gotoh, Masakazu Honma, Kuppusamy Sankar, Indresh Kumar, Hayato Ishikawa, Kohzo Konno, Hiroharu Yui, Seiji Tsuzuki, and Tadafumi Uchimaru Organocatalytic, Enantioselective Intramolecular [6 + 2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study was introduced by SYNFACTS.                                                            Synthesis of (-)-Oseltamivir by Using a Microreactor in the Curtius Rearrangement Eur. J. Org. Chem., 6020 (2011). Hayato Ishikawa, Bojan P. Bondzic and Yujiro Hayashi One-Pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N-Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key step Chem. Eur. J., 17, 11715 (2011). Yujiro Hayashi, Tatsuya Urushima, Daisuke Sakamoto, Kou Torii and Hayato Ishikawa Asymmetric Mannich Reaction of Imines Derived from Aliphatic and Aromatic Aldehydes Catalyzed by Diarylprolinol　Silyl Ether Chem. Eur. J., 17, 8273 (2011). Tatsuya Urushima, Hayato Ishikawa and Yujiro Hayashi                                                  Organocatalyzed Michael Addition of Aldehydes to Nitro Alkenes - Generally Accepted Mechanism Revisited and Revised. Helvetica Chemica Acta, 94, 719 (2011). Krystyna Patora-Komisarska, Meryem Benohoud, Hayato Ishikawa, Dieter Seebach and Yujiro Hayashi One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether was selected as a cover picture of Angew. Chem., Int. Ed.                                                                        Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether Angew. Chem., Int. Ed., 50, 3920 (2011). Yujiro Hayashi, Takahiko Itoh, Hayato Ishikawa Hot Paper                                     Asymmetric One-Pot Four-Component Coupling Reaction: Synthesis of Substituted Tetrahydropyrans Catalyzed by Diphenylprolinol Silyl Ether Angew. Chem., Int. Ed., 50, 3774 (2011). Hayato Ishikawa, Satoshi Sawano, Yusuke Yasui, Yusuke Shibata and Yujiro Hayashi                                               Prof. Hayashi is an invited speaker at CATAFLU.OR Symposium, Bologna, Italy on March 24 th. One-Pot Synthesis of Chiral α-Substituted β,γ-Epoxy Aldehyde Derivatives through an Asymmetric Aldol Reaction of Chloroacetaldehyde Angew. Chem., Int. Ed., 50, 2804 (2011). Yujiro Hayashi, Yusuke Yasui, Tsuyoshi Kawamura, Masahiro Kojima and Hayato Ishikawa    Diarylprolinol in the Direct Asymmetric Aldol Reaction of Trifluoromethylacetaldehyde Ethyl Hemiacetal with aldehyde Synlett, 485, (2011). Yujiro Hayashi, Yusuke Yasui, Tsuyoshi Kawamura, Masahiro Kojima and Hayato Ishikawa One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether Angew. Chem., Int. Ed., 50, 2824 (2011). Hayato Ishikawa, Masakazu Honma, and Yujiro Hayashi Very Important Paper One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by Diphenylprolinol Silyl Ether was introduced by nature chemical biology. One-Pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by Diphenylprolinol Silyl Ether was introduced by SYNFACTS.                                                                                       Prof. Hayashi was awarded the Chemical Society of Japan Award for Creative Work for 2010. Prof. Hayashi is an invited speaker at 15th and last Oppolzer Lectures, University of Geneva, Switzerland on January 28, 2011. Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction Abstracted in SYNFACTS, 12, 1420, (2010). Asymmetric Epoxidation of α-Substituted Acroleins Catalyzed by Diphenylprolinol Silyl Ether Org.Lett., 12, 5434 (2010). Bojan P. Bondzic, Tatsuya Urushima, Hayato Ishikawa, and Yujiro Hayashi                                                                                                                     High-Yielding Synthesis of the Anti-Influenza Neuraminidase Inhibitor (−)-Oseltamivir by Two “One-Pot” Sequences Chem. Eur. J., 16, 12616 (2010). Hayato Ishikawa, Takaki Suzuki, Hideo Orita, Tadafumi Uchimaru and Yujiro Hayashi         Enantio- and Diastereoselective Synthesis of Piperidines by Coupling of Four Components in a “One-Pot” Sequence Involving Diphenylprolinol Silyl Ether Mediated Michael Reaction Org.Lett., 12, 4588 (2010). Tatsuya Urushima, Daisuke Sakamoto, Hayato Ishikawa, and Yujiro Hayashi                                                                                     Formal Total Synthesis of Fostriecin by 1,4-Asymmetric Induction with an Alkyne-Cobalt Complex Chem. Eur. J., 16, 10150 (2010). Yujiro Hayashi, Hirofumi Yamaguchi, Maya Toyoshima, Kotaro Okado, Takumi Toyo, Mitsuru Shoji                                                       Polymeric Ethyl Glyoxylate in an Asymmetric Aldol Reaction Catalyzed by Diarylprolinol  Org.Lett., 12, 2966 (2010). Tatsuya Urushima, Yusuke Yasui, Hayato Ishikawa, and Yujiro Hayashi                                        Prof. Hayashi is an invited speaker at 21th Banyu Sendai Symposium, Sendai, Japan on June 5, 2010. Most cited paper published in Angew. Chem. Int. Ed. from 2007 to 2008 Rank 8th